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Men’s health, measured

The longevity aisle is full of promises. This page isn’t.

NAD+, sermorelin, and B12 — what they actually are, what the evidence actually shows, and a licensed medical provider who will tell you when the answer is no.

There is an entire industry built on selling men the idea that aging is a problem you can buy your way out of. NAD+ drips, peptide "protocols," vitamin shots with the word optimize stamped on them. Some of the underlying compounds are real and worth understanding. Almost none of the marketing around them is honest. This page is the honest version: what these are, where the science is solid and where it’s thin, and a private review by a medical provider who decides what — if anything — is appropriate for you.

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A man submerged shoulders-deep in a cold plunge pool at dawn

The part every longevity ad leaves out.

The evidence behind this whole category is thinner than the marketing, and anyone who tells you otherwise is selling. Plainly: NAD+ is a real coenzyme, but the human evidence that supplementing it slows aging or improves performance is limited and early — most of the striking findings come from cell and animal studies. Sermorelin has no FDA-approved product on the market today, for any use; it is available only as a compounded medication. Extra B12 helps mainly if you're genuinely deficient. All three are compounded and not FDA-approved. Start the assessment; a licensed medical provider tells you what — if anything — is worth it for you, and nothing is a real answer.

Nobody looks into this because a lab told them to.

You noticed it in the recovery before you noticed it anywhere else. The training day that used to cost you an afternoon now costs you most of the week. Sleep is lighter than it was. Some mornings the guy in the mirror looks like he’s running on a lower setting, and you’d like to feel like yourself again — whatever that costs.

That’s a real experience, and it’s a fair reason to look. Here’s the part the longevity funnels leave out: whether any of these compounds change what you’re feeling is an open question with an honest answer, and the honest answer starts with a medical provider looking at you — your history, your labs where they matter — not a checkout page that already decided you need six subscriptions. We’d rather tell you what’s known, what isn’t, and let a provider make the call.

A vital, healthy couple in their fifties

Seven compounds, and very different stories.

The word longevity gets slapped on all of these as if they were one thing. They aren’t. Here’s the plain version of the three we get asked about most — and an honest note on the rest.

NAD+
NAD+ (injection, nasal, or oral dropper). NAD+ — nicotinamide adenine dinucleotide — is a coenzyme found in every cell in your body. Its job is chemistry: it’s central to how cells convert fuel into usable energy and to several cellular-repair pathways. That is a description of what the molecule does inside a cell, not a claim about how you’ll feel. NAD+ has become one of the most hyped compounds in the wellness market, which is exactly why the evidence section below matters more than the marketing.
Sermorelin
Sermorelin (injection). Sermorelin is a synthetic peptide — a fragment of the natural signal (growth-hormone-releasing hormone) your body uses to tell the pituitary gland to release growth hormone. Instead of supplying a hormone from outside, it nudges your own gland to do its own signaling. One fact stated up front, because most sites bury it: there is no FDA-approved sermorelin product on the market today. It is available only as a compounded medication.
B12 MIC
B12 MIC (injection). This is methylcobalamin — vitamin B12 — usually combined with MIC, three compounds (methionine, inositol, choline) grouped under the label "lipotropic." B12 has a well-established medical use: correcting a diagnosed B12 deficiency. The broader claims stapled to B12 and MIC shots in people who aren’t deficient are a different matter, and the evidence section is honest about that too.

Also available, and treated the same way

Your provider can also prescribe glutathione, methylene blue, Lipo-C, or L-carnitine as compounded preparations. We are going to be as plain about these as we are about the three above: they are widely marketed for energy, metabolism and "detox," and the human evidence behind those particular marketing claims is limited. They are not FDA-approved, they are not a substitute for treating an underlying cause, and none of them is something we will tell you that you need. They are here because they are part of what a licensed medical provider can consider — not because we think everyone should be on them. Whether any of these fits you is a medical decision made from your history, and no is a real answer.

Where the science is real, and where it’s thin. Both, plainly.

This is the section the rest of the internet skips. Read it before anything else.

NAD+. The biochemistry is not in dispute — NAD+ is essential to cellular metabolism, full stop. What is thin is the human evidence that supplementing it produces the anti-aging or performance results the market implies. Most of the striking findings come from cell and animal studies; well-controlled human trials on hard outcomes are limited and early. Anyone selling NAD+ as a settled fountain-of-youth is ahead of the data. The honest position: interesting compound, active research, unproven for the big promises.
Sermorelin. Sermorelin does what its mechanism says — it can stimulate the body’s own growth-hormone signaling. What the published human evidence does not establish is that this translates into the longevity, body-composition, or vitality outcomes it’s marketed for in healthy adults. Its record is thinner and older than the marketing suggests, and — again — no FDA-approved sermorelin product exists today. It is a compounded medication, and the decision to use one is a medical one.
B12 MIC. If you have a genuine B12 deficiency, correcting it is real, established medicine with real effects. If you don’t, the popular claims — that B12 or MIC shots raise energy, speed metabolism, or drive fat loss in people with normal levels — are not well supported by the evidence. We’re not going to tell you otherwise to sell you a subscription. Whether your levels warrant it is exactly the kind of thing a provider looks at.

The through-line: these are legitimate compounds surrounded by illegitimate promises. A medical provider’s job here is to separate the two for your specific situation.

NAD+
Mechanism / biochemistry
Established — a coenzyme essential to how cells convert fuel into energy; not in dispute.
Human outcome evidence (the big promises)
Thin / early — most striking findings are cell & animal studies; human trials on hard outcomes are limited.
Sermorelin
Mechanism / biochemistry
Plausible — can stimulate the body's own growth-hormone signaling.
Human outcome evidence (the big promises)
Thin / older — longevity/body-composition/vitality outcomes in healthy adults not established; and no FDA-approved sermorelin product today.
B12 MIC
Mechanism / biochemistry
Established for one use — correcting a documented B12 deficiency is real medicine.
Human outcome evidence (the big promises)
Not well supported — raising energy, speeding metabolism, or driving fat loss at normal levels.
A high mechanism reading is not an outcome: "involved in cellular energy" is chemistry, not a promise about how you'll feel.
A compounded NAD+ vial and syringe on a clean surface

The actual numbers. Billed as stated, no surprise price hikes.

Everything below is prescription-only and provider-gated: whether any of it is appropriate for you, and which one, is decided by a licensed medical provider from your health history — not self-selected from a menu. Prices are per 28-day supply; multi-week plans are billed once per term. A 28-day cycle means 13 cycles across a 364-day year — that’s the real arithmetic, and we’d rather you do it before you start.

NAD+ (compounded injection, nasal, or oral dropper) & Sermorelin (compounded injection)
Starting out$149 your first 4 weeks, then $199 per 28 days
Flexible$199 per 28 days, billed every 28 days
12-week plan$169 per 28 days · billed $507 every 12 weeks
24-week plan$149 per 28 days · billed $894 every 24 weeks
52-week plan$109 per 28 days · billed $1,417 every 52 weeks
B12 MIC, glutathione, methylene blue, Lipo-C, or L-carnitine (compounded)
Starting out$95 your first 4 weeks, then $145 per 28 days
Flexible$145 per 28 days, billed every 28 days
12-week plan$129 per 28 days · billed $387 every 12 weeks
24-week plan$119 per 28 days · billed $714 every 24 weeks
52-week plan$109 per 28 days · billed $1,417 every 52 weeks

These cards are informational. You don’t pick a plan here — your medication and plan options are confirmed at the end of the medical intake, after a licensed medical provider has reviewed your history and determined what’s appropriate to offer you. The first-4-weeks rate applies once, at the start. Cancel any time; future cycles stop billing.

Start Your Assessment

Reviewed by a person. Rechecked on a real schedule.

1
Assessment — an online intake, about 3–5 minutes: health history, medications, what’s changed, what you’re actually after. Completing it costs nothing.
2
Provider review — a medical provider licensed in your state reviews your case asynchronously, typically within 24–48 hours. Not an algorithm. Not a sales page. If nothing here is appropriate for you, this is where you’ll hear it.
3
Refill review — if you’re prescribed something, your initial supply runs up to 24 weeks. Refills are reviewed by your medical provider on a 12- to 24-week cadence depending on the compound, and you can ask for a live consult at any point at no extra cost.
4
Ships, then stays reviewed — if prescribed, your medication ships from a state-licensed compounding pharmacy in discreet packaging, and refill reviews with your medical provider every 12 weeks keep the prescription honest.
See the Options

Read this part even if you skip the rest.

These are medical products, not groceries. An injectable or intranasal compound goes into your body and interacts with the rest of your health. That is why the model is provider-gated and why the honest answer is sometimes no.
Who gets a closer look — or a no. Active cancer, certain hormone-sensitive conditions, pregnancy in a partner where relevant to timing, significant kidney or liver issues, and a range of other histories can make one or more of these inappropriate. The full list isn’t something a web page can complete — your history and your provider decide.
The everyday list. Injectable and intranasal products can cause injection-site or nasal irritation, flushing, headache, nausea, or lightheadedness in some people; individual reactions vary. Your medical provider reviews your specific risk and tells you what to watch for.
Supplements and stacking. Tell your provider everything you already take, including over-the-counter "longevity" and "peptide" products bought online — regulators have repeatedly found unregulated wellness products to contain undisclosed ingredients at unknown doses.
This isn’t primary care. These programs don’t replace a relationship with your own doctor, and nothing here is a substitute for evaluation of a symptom that needs one.

All of this is why the model is provider-gated. Your medical provider decides — and the answer might be no. That’s the feature, not the fine print.

What these are — and what they aren’t.

The NAD+ and sermorelin offered through this program are compounded medications, and they are not FDA-approved. Sermorelin goes a step further: there is no FDA-approved sermorelin product for any use on the market today, so there isn’t even a branded original to compare a compounded version against. The B12 MIC injections are compounded preparations as well.

Compounded means each preparation is made to a medical provider’s prescription by a state-licensed compounding pharmacy — a real, regulated pathway, and a different regulatory category from an FDA-approved drug that has been through the agency’s full review. That distinction is not a technicality we’re required to mumble; it’s information you should have before you decide. You’ll see other sites blur it, or imply these compounds are proven to do things the evidence doesn’t support. We’re required not to — and we wouldn’t anyway, because the men reading this page can handle the actual facts.

FDA-approved drugs
Review pathwayHas been through the FDA’s full review before reaching the market.
Who prepares itManufactured under the FDA-approval framework, with agency-reviewed labeling.
What that means for youThe product and the claims on its label were reviewed by the agency.
Compounded preparations
Review pathwayNot FDA-approved — a different regulatory category, with no FDA review of the preparation itself.
Who prepares itMade to a medical provider’s prescription by a state-licensed compounding pharmacy.
What that means for youA real, regulated pathway — and information you should have before you decide.

Straight answers, short version.

A confident woman
Will this make me feel younger?
That’s the promise the whole category oversells. The honest answer: these compounds are real, the big anti-aging claims around them are largely unproven in humans, and a medical provider decides what — if anything — fits your situation.
Is sermorelin FDA-approved?
No. There is no FDA-approved sermorelin product on the market today; it’s available only as a compounded medication. We say so on purpose.
Does a B12 shot raise energy?
If you’re genuinely deficient, correcting it is real medicine. If your levels are normal, the popular energy and metabolism claims aren’t well supported — which is why a provider looks at whether it’s warranted for you.
Do I need labs first?
Sometimes. Your provider orders labs when your history or a specific compound calls for it, rather than as a blanket upsell.
Can I just order the whole stack?
No. Which compound — or whether any is appropriate — is your medical provider’s decision, made from your health history.
Can I stop?
Yes — cancel any time and future cycles stop billing.
Still have more questions? Read the full FAQ →

From the Learn library

Two plain-language guides that go deeper than this page — what NAD+ evidence really shows, and what to know about sermorelin before you consider it.

What Is NAD+ — and What the Evidence Actually Shows
Learn · Longevity

What Is NAD+ — and What the Evidence Actually Shows

A real coenzyme wrapped in unreal promises. Where the human evidence is thin, said plainly.

Read the guide →
Sermorelin: What to Know Before You Consider It
Learn · Longevity

Sermorelin: What to Know Before You Consider It

The secretagogue mechanism, and the fact most sites bury: no FDA-approved product today.

Read the guide →

This isn’t for everyone.

Some men who complete this assessment won’t be prescribed anything here — their history rules it out, their labs don’t support it, or the honest read is that a compound isn’t going to give them what they came for. If that’s you, a medical provider will tell you directly, before you pay for treatment. That’s not the system failing. That’s the system.

If something here is appropriate for you, you’ll get it on a real schedule — reviewed early, rechecked on a term, at the prices printed above — with none of the promises the rest of the category runs on.

Either way, you leave with the facts instead of a fantasy.

Start Your AssessmentSee the Options
Gentlemen’s Health Collective is a men’s telehealth platform and does not provide medical services; all medical care is provided by our medical provider partner, an independent network of US-licensed medical providers. All medical decisions — including whether treatment is appropriate, which compound, and at what dose — are made by a medical provider licensed in your state; prescriptions are issued only where clinically appropriate. Compounded preparations of NAD+, sermorelin, B12 MIC, glutathione, methylene blue, Lipo-C, and L-carnitine are not FDA-approved; they are prepared to a medical provider’s prescription by state-licensed compounding pharmacies operating under USP <795> and/or USP <797> standards, and are distinct from FDA-approved drugs that have completed the agency’s full review. There is no FDA-approved sermorelin product on the market for any use. Statements on this page have not been evaluated by the FDA and describe no diagnosis, treatment, cure, or prevention of any disease; individual results vary. Prices shown are per 28-day supply; multi-week plans are billed once per term as shown ("$507 billed every 12 weeks" = $169 per 28-day supply); a 28-day billing cycle results in 13 billing cycles per 364 days. The reduced first-4-weeks rate applies once, to a first 28-day supply. No surprise price hikes — any pricing change is communicated in advance, before it affects a billing cycle. 100% self-pay; insurance is not required or billed. Cancel any time; future billing cycles stop; past payments are not refundable except as set out in our Refund Policy. This program is not a substitute for primary medical care, and this page is general information, not medical advice. If you are experiencing a medical emergency, call 911. If you are struggling with low mood or thoughts of self-harm, call or text 988 (Suicide & Crisis Lifeline), any hour.